The club includes two 18-hole courses and hosted the Canadian Open five times, most recently in 1974 when Bobby Nichols won. The club (and the city) are named in honor of the Mississauga band of the Ojibwe nation that once occupied the land.

The Old Course was originally a 9-hole layout designed by Percy Barrett in 1906, later completed by George Cumming in 1909. However, the legendary Canadian architect Stanley Thompson oversaw a major redesign in 1928, a design that led to the club hosting the 1931 Canadian Open, won by the great Walter Hagen.

This is a private club; visitors are permitting only as guests of members.